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Haspin inhibitors did not block Aurora B localization to the spindlemidzone in anaphase or Aurora B function in cytokinesis.
2
Error-free cell division depends on the assembly of the spindlemidzone, a specialized array of overlapping microtubules that emerges between segregating chromosomes during anaphase.
3
Spindle checkpoint proteins accumulate mainly within the spindlemidzone and inhibit anaphase onset.
Usage of central spindle in English
1
Centralspindlin is essential for centralspindle and cleavage furrow formation.
2
Saul launched himself towards the centralspindle, which seemed the quickest way to the other end.
3
These components and the chromosomal passenger complex localize to the centralspindle, though no furrow forms there.
4
Early Drosophila embryogenesis is characterized by shifting from astral microtubule-based to centralspindle-based positioning of cleavage furrows.
5
Accordingly, we find that ectopic activation of Rho GTPase generates furrows perpendicular to the centralspindle during syncytial divisions.
6
These studies demonstrate that early Drosophila embryogenesis is primed to form furrows at either overlapping astral microtubules or the centralspindle.
7
Thus, Tek2-dependent organization of the centralspindle during anaphase is essential for proper midbody formation and the segregation of daughter cells after cytokinesis.
8
In this, before firing, the needle pellet is held back by a centralspindle with a pressure plate attached to its rear end.
9
The font had a vertical centralspindle that rose halfway up and flattened into a kind of small metal platter just above the water.